New Immunotherapeutic Options for Triple-Negative and Brain Metastatic Breast Cancer: Next-Generation Cancer Vaccines Exploiting Alternative Classes of Tumour Antigens

CBL0137 and NKG2A blockade: a novel immuno-oncology combination therapy for Myc-overexpressing triple-negative breast cancers

PV Raninga, B Zeng, D Moi, E Trethowan, F Saletta, P Venkat, C Mayoh, RCJ D’Souza, BW Day, T Shai-Hee, O Vittorio, R Mazzieri, R Dolcetti, KK Khanna

2025-04-14

The MYC proto-oncogene is upregulated in >60% of triple-negative breast cancers (TNBCs), it can directly promote tumor cell prolif..

Are monocytes a preferable option to develop myeloid cell-based therapies for solid tumors?

D Bhatia, R Dolcetti, R Mazzieri

2025-01-01

In the last two decades, novel and promising cell-based therapies have populated the treatment landscape for haematological tumors..

Targeting Tumor Heterogeneity with Neoantigen-Based Cancer Vaccines

S Pounraj, S Chen, L Ma, R Mazzieri, R Dolcetti, BHA Rehm

2024-02-01

Neoantigen-based cancer vaccines have emerged as a promising immunotherapeutic approach to treat cancer. Nevertheless, the high de..

Skin-Grafting and Dendritic Cell “Boosted” Humanized Mouse Models Allow the Pre-Clinical Evaluation of Therapeutic Cancer Vaccines

B Zeng, D Moi, L Tolley, N Molotkov, IH Frazer, C Perry, R Dolcetti, R Mazzieri, JLG Cruz

2023-08-01

Vaccines have been hailed as one of the most remarkable medical advancements in human history, and their potential for treating ca..

Multiparametric flow cytometry to characterize vaccine-induced polyfunctional T cell responses and T cell/NK cell exhaustion and memory phenotypes in mouse immuno-oncology models

D Moi, B Zeng, SA Minnie, R Bhatt, J Wood, DP Sester, R Mazzieri, R Dolcetti

2023-01-01

Suitable methods to assess in vivo immunogenicity and therapeutic efficacy of cancer vaccines in preclinical cancer models are cri..

Understanding the immuno-biology of oesophageal adenocarcinoma: Towards improved therapeutic approaches

JM Lonie, AP Barbour, R Dolcetti

2021-07-01

With an incidence that is constantly rising, oesophageal adenocarcinoma (OAC) is becoming an increasing health burden worldwide. A..

Reprogramming the anti-tumor immune response via CRISPR genetic and epigenetic editing

E Alves, S Taifour, R Dolcetti, J Chee, AK Nowak, S Gaudieri, P Blancafort

2021-06-11

Precise clustered regularly interspaced short palindromic repeats (CRISPR)-mediated genetic and epigenetic manipulation of the imm..

Characterization of immune cell subsets of tumor infiltrating lymphocytes in brain metastases

P Kalita-De Croft, H Chittoory, TH Nguyen, JM Saunus, WG Kim, AE McCart Reed, M Lim, XM De Luca, K Ferguson, C Niland, R Mazzieri, R Dolcetti, PT Simpson, SR Lakhani

2021-05-01

The heterogeneity of tumor infiltrating lymphocytes (TILs) is not well characterized in brain metastasis. To address this, we perf..